Antihypertensive; angiotensin II receptor antagonist.

Hypertension, Hypertension with left ventricular hypertrophy, Nephropathy diabetic.

FDA Pregnancy Category C

Pregnancy, Breast-feeding: It is not known whether losartan is distributed into breast milk.

Contraindications

Except under special circumstances, this medication should not be used when the following medical problem exists:

Hypersensitivity to losartan or any component of the product.

Risk-benefit should be considered when the following medical problems exist

Hepatic function impairment, Renal artery stenosis, bilateral or in a solitary kidney, Renal function impairment, moderate to severe.

Drug Interactions

Anti-inflammatory drugs, nonsteroidal (NSAIDs), especially indomethacin, Blood from blood bank, Cyclosporine, Diuretics, potassium-sparing ,Low-salt milk, Potassium-containing medications, Potassium supplements, substances containing high concentrations of potassium, Salt substitutes, Diuretics, Fluconazole,  Hypotension-producing medications other, Sympathomimetics,  

Antihypertensive-

Initial- Oral, 50 mg once a day.

Note: in patients with possible volume depletion and patients with history of hepatic function impairment an initial dose of 25 mg once a day is recommended.

Maintenance- Oral, 25 to 100 mg a day. Does may be given once a day or divided into two doses.

Note: If adequate blood pressure control is not achieved by losartan alone, a low dose of a diuretic may be added for an additive effect.

Hypertension with left ventricular hypertrophy(treatment) - Oral usal starting dose 50 mg once daily Hydrochlorothiazide 12.5 mg once daily should be added and/or losartan dose should not be increased to 100 mg once daily followed by an increase in Hydrochlorothiazide to 25 mg once based pressure response.

Hypertrophy, diabetic(treatment)- Oral usual starting dose 50 mg once daily Dose should be increased to 100mg once daily based on blood  pressure response.

Note: Losartan may be administered with insulin and other commonly used hypoglycemic agents( e.g. sulfonylureas, glitazones and glucosidase inhibitors.

Antihypertensive- Children younger than 6 years of age - Safety and efficacy have not been established.

Children 6 years of age and older - Oral initial dose of 0.7 mg per kg of body weight per day up to 50 mg per day.

Note: Losartan should not be administered to pediatric patients with creatinine clearance

Those indicating need for medical attention

Incidence less frequent

Dizziness; upper respiratory infection

Incidence unknown - Observed during clinical practice, estimates of frequency cannot be determined.

Angioedema, hepatitis, hyperkalemia, hyponatremia, rhabdomyolysis, thrombocytopenia, vasculitis including, Henoch- Schonlein purpura

Those indicating need for medical attention only if they continue or are bothersome

Incidence more frequent

Headache

Incidence less frequent

Back pain; diarrhea; fatigue; nasal congestion

Incidence rare

Cough, dry; insomnia (trouble in sleeping); leg pain; muscle cramps or pain; sinus problems.

Store below 30°C (86 °F)

Keep the medicine in the box.

Box of 30 Scored F.C Tablets Losartan 25mg